Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
نویسندگان
چکیده
منابع مشابه
Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin
Cyclin-dependent kinase (Cdk) both promotes mitotic entry (spindle assembly and anaphase) and inhibits mitotic exit (spindle disassembly and cytokinesis), leading to an elegant quantitative hypothesis that a single cyclin oscillation can function as a ratchet to order these events. This ratchet is at the core of a published ODE model for the yeast cell cycle. However, the ratchet model requires...
متن کاملThe mitotic exit network
What is it? The mitotic exit network – commonly known by the acronym MEN — is a signal transduction cascade which triggers the exit of mitosis. The MEN has been characterized in the budding yeast Saccharomyces cerevisiae, and the protein names below refer to components from this species, though many are conserved in vertebrates. The main switch of this cascade is the small G protein Tem1 and it...
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The exit from mitosis is the last critical decision during a cell-division cycle. A complex regulatory system has evolved to evaluate the success of mitotic events and control this decision. Whereas outstanding genetic work in yeast has led to rapid discovery of a large number of interacting genes involved in the control of mitotic exit, it has also become increasingly difficult to comprehend t...
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B-type cyclins promote mitotic entry and inhibit mitotic exit. In Saccharomyces cerevisiae, four B-type cyclins, Clb1-4, carry out essential mitotic roles, with substantial but incomplete overlap of function among them. Previous work in many organisms has indicated that B-type cyclin-dependent inhibition of mitotic exit imposes a requirement for mitotic destruction of B-type cyclins. For instan...
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The mitotic exit network (MEN) is an essential GTPase signaling pathway that triggers exit from mitosis in budding yeast. We show here that during meiosis, the MEN is dispensable for exit from meiosis I but contributes to the timely exit from meiosis II. Consistent with a role for the MEN during meiosis II, we find that the signaling pathway is active only during meiosis II. Our analysis furthe...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2009
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2009.78