Anion effects on pyruvate kinase (Short Communication)
نویسندگان
چکیده
منابع مشابه
Prevalence of Pyruvate Kinase Deficiency among the Newborns (Shiraz-Iran)
Background: The frequency of pyruvate kinase (PK) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in Shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. The purpose of this study is to obtain data on the frequency and spectrum of gene mutation of PK in newborns, from Shiraz and surrounding areas. Materials and Methods...
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Unlike the usual “kinase” reaction between ATP and an alcohol, pyruvate kinase catalyzes phosphate transfer to an oxygen which in the substrate, pyruvate, is in carbonyl linkage. It is of particular interest to ask whether enolization of pyruvate occurs sufficiently rapidly under physiological conditions so that the true substrate for the enzyme may be the enol form of pyruvate. In the work rep...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1974
ISSN: 0264-6021
DOI: 10.1042/bj1430255