Antenatal dexamethasone and the growth hormone–insulin-like growth factor axis
نویسندگان
چکیده
منابع مشابه
The growth hormone-insulin-like growth factor-I axis.
The aim of the GH-2000 project is to develop a method for detecting GH doping among athletes. Previous papers in the GH-2000 project have proposed that a forthcoming method to detect GH doping will need specific components from the GH/IGF-I axis and bone markers because these specific variables seem more sensitive to exogenous GH than to exercise. The present study examined the responses of the...
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Long-term effects on lung size and lung mechanics were sought in a 12-month follow-up study of 15 infants of very low birthweight (less than 1500 g), 7 of whom had been exposed to antepartum dexamethasone (mean dose 21 mg). None of the infants had significant neonatal respiratory disease. No differences were found between the dexamethasone-treated and control groups for thoracic gas volume, dyn...
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Severe chronic metabolic acidosis (CMA) in rats is associated with poor food intake and downregulation of growth hormone (GH), insulin-like growth factors (IGFs), and liver receptors; the administration of recombinant GH (rGH) fails to improve the growth failure. In mice with carbonic anhydrase II deficiency (CAD), a model of moderate CMA with food intake close to normal, we studied serum level...
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The ontogeny of the somatotropin/insulin-like growth factor system was examined in well-fed pigs under basal conditions and during a short-term challenge of porcine ST (pST). The study was conducted with two replicates of eight castrate male pigs from 3.8 kg BW (10 d of age) to 92 kg BW (129 d of age). Pigs were reared individually with ad libitum access to milk replacer through 23 d of age. Th...
متن کاملInsulin-like growth factor-I: compartmentalization within the somatotropic axis?
Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2000
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/15.6.1403