Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element

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Anti-HCV RNA Aptamers Targeting the Genomic cis-Acting Replication Element

Hepatitis C virus (HCV) replication is dependent on the existence of several highly conserved functional genomic RNA domains. The cis-acting replication element (CRE), located within the 3' end of the NS5B coding region of the HCV genome, has been shown essential for efficient viral replication. Its sequence and structural features determine its involvement in functional interactions with viral...

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ژورنال

عنوان ژورنال: Pharmaceuticals

سال: 2011

ISSN: 1424-8247

DOI: 10.3390/ph5010049