ANTI-NICOTINIC ACTION OF VAST AREL® ON GUINEA-PIG ATRIA
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چکیده
منابع مشابه
Effect of Sodium Valproate on Ouabain-Induced Arrhythmia in Isolated Guinea-Pig Atria
Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...
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Endothelin (ET), a novel 21-amino acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, has been shown to be the most potent of all known vasoconstrictor substances. The purpose of the present study was to investigate the effects and the mode of actions of ET on the heart. ET exerted a positive inotropic effect in a dose-dependent manner on the electrically dri...
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中沢 与 四郎 ・上野 昭 During the investigation of atrial anaphylaxis, positive inotropic effects of various drugs have been compared with that of the anaphylactic manifestation in the isolated guinea pig atria, it was observed that thiamine derivatives increased the contractile force of the atrium. Thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide (TTFD) are allithiamine derivat...
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Guinea pig right atria were perfused in vitro at 30°C. When the temperature was lowered to about 20°C, atrial activity ceased and the resting potential of atrial fibers decreased significantly. When activity was restored during hypothermia by electrical stimulation, both the resting and the action potentials were similar to those recorded at 30°C. Blockade of receptors by atropine or propranolo...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1969
ISSN: 0021-5198
DOI: 10.1254/jjp.19.628