Antibacterial activity of substances related to p-aminobenzoic acid
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چکیده
منابع مشابه
Separation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملTHE ANTIBACTERIAL ACTION OF DERIVATIVES AND ANALOGUES OF p-AMINOBENZOIC ACID
The bacteriostasis induced by the sulfonamide drugs is reversed by p-aminobenxoic acid (PAB) in appropriate concentrations (1). It is now well established that PAB is a normal constituent of cells (2) and that the bacteriostatic effects of the sulfonamides are explicable in terms of their structural similarity to PAB (3). The precise rble of PAB in cellular metabolism has yet to be clarified bu...
متن کاملEffect of structurally related compounds on the oxidation of p-aminobenzoic acid by Pseudomonas fluorescens.
The realization that p-aminobenzoic acid is essential as a growth factor has stimulated extensive research in the field of antagonists of this essential metabolite. Woods (1940) and Woods and Fildes (1940) reported that yeast contained a substance, identified as p-aminobenzoic acid, that could protect it against the growth inhibiting action of sulfanilamide. Youmans et al. (1947) reported the t...
متن کاملTHE ISOLATION OF p-AMINOBENZOIC ACID FROM YEAST
The present investigation is primarily concerned with the isolation of p-aminobenzoic acid from yeast. The presence of this substance in yeast was adumbrated by Woods (1) who made the important discovery that. this aromatic amino acid possesses the unique propcity of antagonizing the bsctcriostat~ic action of sulfanilamidt? and that the component. of yeast extracts which exerts a similar antisu...
متن کاملMetabolic conjugations of p-aminobenzoic acid in the rat.
The acetylation of p-aminobenzoic acid (PAB) (2) and of sulfanilamide (3) by the rat has been shown to depend upon an adequate supply of pantothenic acid, a constituent of the coenzyme A molecule (4). In addition the extent of acetylation is decreased by giving large amounts of PAB with reference to the size of the animal (5, 6) and to a smaller extent by a deficiency of riboflavin (5). The pre...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1945
ISSN: 0306-3283
DOI: 10.1042/bj0390091