Antibacterial resistance of modified woven vascular prostheses in experimental infected wound modeling

Objective . To optimize the composition of polymer coatings based on assessment duration antibacterial resistance in infected wounds laboratory animals. Materials and methods Woven vascular prostheses consisting fibrous-porous polypropylene one three types a polyvinyl-chitosan complex with addition biologically active substances were used study. All samples impregnated 1% vancomycin for 30 minutes. The research were: bacteriological, molecular genetic methods. Qualitative results during study period groups confirmed or more repetitions results. Results In qualitative according to PCR bacteriological studies, woven containing polyvinyl alcohol, polyvinylpyrrolidone, chitosan, antibiotic vancomycin, hyaluronic acid do not get S. aureus up four days, L-aspartic L–aspartic five days. Conclusion presence increases comparison acid. polyvinylpyrrolidone significantly (p = 0.012) reduces contamination , increasing prostheses, whereas alcohol does have such an effect.