Antibiotic Hypersensitivity Mechanisms
نویسندگان
چکیده
منابع مشابه
Bacterial evolution of antibiotic hypersensitivity
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity. In this case, genetic adaptation under antibiotic stress yields enhanced sensitivity to other antibiotics. Using large-scale laboratory evolutiona...
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Before initiating antibiotic therapy, drug hypersensitivity is an important consideration, and a common strategy is to avoid giving patients medications when a high likelihood of severe reactions exists. With an increase in antibiotic resistance and a decrease in novel antibiotics, there is greater pressure to consider antibiotics in patients with a history of adverse reactions. The major conce...
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Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...
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Jun Lin, Kunihiko Nishino, Marilyn C. Roberts, Marcelo Tolmasky, Rustam I. Aminov and Lixin Zhang* 1 Department of Animal Science, The University of Tennessee, Knoxville, TN, USA 2 Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan 3 Department of Environmental and Occupational Health Sciences, University of Washington, Seatle, WA, USA 4 Center for Applied Biotechno...
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Human leukocytes, isolated from the blood of ragweed-sensitive donors, release histamine upon reaction with a purified protein antigen derived from this pollen. The release process has been studied with washed cells suspended in a defined, serum-free medium. Physiologic levels of pH, ionic strength, and temperature, as well as both calcium and magnesium, are required for optimal cellular reacti...
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ژورنال
عنوان ژورنال: Pharmacy
سال: 2019
ISSN: 2226-4787
DOI: 10.3390/pharmacy7030122