Antifungal drug resistance: evolution, mechanisms and impact
نویسندگان
چکیده
منابع مشابه
Antifungal drug resistance of yeasts in dermatology: mechanisms, epidemiology and clinical impact
Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents....
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Mechanisms of antifungal resistance
The many drugs that are available at present to treat fungal infections can be divided into four broad groups on the basis of their mechanism of action. These antifungal agents either inhibit macromolecule synthesis (flucytosine), impair membrane barrier function (polyenes), inhibit ergosterol synthesis (allylamines, thiocarbamates, azole derivatives, morpholines), or interact with microtubules...
متن کاملThe potential impact of antifungal drug resistance mechanisms on the host immune response to Candida
A large number of studies have been published over the last two decades examining molecular mechanisms of antifungal resistance in Candida species. However, few of these studies have explored how such mechanisms influence the host immune response to this opportunistic pathogen. With recent advances in our understanding of host immunity to Candida, a body of emerging literature has begun to expl...
متن کاملAntifungal drug resistance.
The increasing incidence of invasive fungal infections is the result of many factors, including an increasing number of patients with severe immunosuppression. Although new drugs have been introduced to combat this problem, the development of resistance to antifungal drugs has become increasingly apparent, especially in patients who require long-term treatment or who are receiving antifungal pr...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2018
ISSN: 1369-5274
DOI: 10.1016/j.mib.2018.02.005