Antimicrobial peptides – Advances in development of therapeutic applications
نویسندگان
چکیده
منابع مشابه
Antimicrobial peptides for therapeutic applications: a review.
Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to conventional antibiotics. Although AMPs possess considerable benefits as new generation antibiotics, their clinical and commercial development still have some limitations, such as potential toxicity, s...
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Volume 5 • Issue 3 • 2013 Antimicrobial peptides (AMPs) are small proteins (<100 amino acids) which include alpha-defensins, beta-defensins and the cathelicidin LL-37 in humans [1]. Alpha-defensins are expressed in neutrophils as part of their non-oxidative antimicrobial mechanismsand are also found in Paneth cells in the intestine [2,3]. They are synthesized as precursors that are proteolytica...
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Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and to the clinic in the last three decades. This review highlights the properties of a new class of antibiotics, namely dendrimeric peptides. These i...
متن کاملAvian Antimicrobial Host Defense Peptides: From Biology to Therapeutic Applications
Host defense peptides (HDPs) are an important first line of defense with antimicrobial and immunomoduatory properties. Because they act on the microbial membranes or host immune cells, HDPs pose a low risk of triggering microbial resistance and therefore, are being actively investigated as a novel class of antimicrobials and vaccine adjuvants. Cathelicidins and β-defensins are two major familie...
متن کاملAntimicrobial Peptides as Therapeutic Agents
Copyright © 2012 Mathew Upton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In developing this special issue, we sought to raise awareness of the potential of antimicrobial peptides (AMPs) for clinical use and to highligh...
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ژورنال
عنوان ژورنال: Life Sciences
سال: 2020
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2020.118407