Antitubercular 2-Pyrazolylpyrimidinones: Structure–Activity Relationship and Mode-of-Action Studies
نویسندگان
چکیده
منابع مشابه
postnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)
1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
the investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics.
Organometallic complexes with thiopyrone-based ligands have shown promising cytotoxic activity in vitro. To investigate the impact of the ligand backbone modification of these biologically active compounds and enhance the solubility in aqueous solution, the (thio)pyrone scaffold was modified via Suzuki-Miyaura coupling reaction and converted into corresponding organometallic Ru(ii) and Rh(iii) ...
متن کامل1278 MODE OF ACTION OF 2 - MERCAPTOETttANOI
It has been reported by many authors that a variety of thiol compounds augment various lymphocyte reactions in vitro, including antibody responses (1, 2), induction of cytotoxic T cells in the mixed lymphocyte culture (3, 4), and the DNA synthetic response to mitogens (5-7). 2-Mercaptoethanol (2-ME), 1 one of the most effective thiols, was shown to be a polyclonal activator of both T cells (8) ...
متن کاملNitazoxanide: nematicidal mode of action and drug combination studies.
Intestinal nematodes or roundworms (aka soil-transmitted helminths or STHs) cause great disease. They infect upwards of two billion people, leading to high morbidity and a range of health problems, especially in infected children and pregnant women. Development of resistance to the two main classes of drugs used to treat intestinal nematode infections of humans has been reported. To fight STH i...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2021
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.0c01727