Antiviral effect of interferon lambda against West Nile virus
نویسندگان
چکیده
منابع مشابه
West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein.
The human MxA protein is a type I and III interferon (IFN)-induced protein with proven antiviral activity against RNA viruses. In this study, we investigated the effect of MxA expression on the replication of West Nile Virus strain Kunjin (WNV(KUN)). Pretreatment of A549 cells with IFN-alpha lead to increased expression of MxA, which contributed to inhibition of WNV(KUN) replication and secreti...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2009
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2009.03.006