Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome
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چکیده
منابع مشابه
Induction of Macrophage Chemotaxis by Aortic Extracts from Patients with Marfan Syndrome Is Related to Elastin Binding Protein
Marfan syndrome is an autosomal dominantly inherited disorder of connective tissue with prominent skeletal, ocular, and cardiovascular manifestations. Aortic aneurysm and dissection are the major determinants of premature death in untreated patients. In previous work, we showed that extracts of aortic tissues from the mgR mouse model of Marfan syndrome showed increased chemotactic stimulatory a...
متن کاملDissecting aortic aneurysm with Marfan syndrome.
Examination revealed an asthenic built child with height of 162 cm, arm span 174 cm, arm span-toheight ratio 1.074 and US:LS ratio 0.82. He had high arched palate, arachnodactly, positive wrist and thumb signs. There were signs of consolidation over left base. Cardiovascular system examination revealed a short diastolic murmur in aortic space. Skiagram revealed a massive consolidation of left l...
متن کامل[Letter to the Editor] DNA Fragmentation Is Not Associated with Apoptosis in Zerumbone-induced HepG2 Cells
Zerumbone is a cytotoxic compound isolated from the herbal plant, Zingiber zerumbet Smith, which exhibits antitumor activity [1-2], anti-inflammatory effects and possesses anti-proliferative potentials in a variety of cell lines [3-4]. DNA fragmentation indicates an early event of apoptosis leading to cell death due to the absence of new cellular proteins synthesizing for cell survival. Previou...
متن کاملMarfan syndrome is not associated with intracranial aneurysms.
BACKGROUND AND PURPOSE It has been proposed that patients with Marfan syndrome have an increased prevalence of intracranial aneurysms. This proposition is based on 10 clinical reports, 1 pathology case, and an autopsy series of 7 patients. By contrast, 5 clinical series of Marfan patients have failed to document any such relationship. We present our institution's autopsy and clinical experience...
متن کاملIs Marfan syndrome associated with symptomatic intracranial aneurysms?
BACKGROUND AND PURPOSE Marfan syndrome is a heritable disorder of connective tissue caused by a deficiency of the glycoprotein fibrillin. In several publications and neurological textbooks, a relationship between Marfan syndrome and intracranial aneurysms has been assumed. METHODS The records of 135 patients classified as having Marfan syndrome who visited the Amsterdam Marfan clinic or were ...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2017
ISSN: 0022-3417
DOI: 10.1002/path.4949