Apolipoprotein E ɛ4, Cognitive Function, and Pain Experience in Down Syndrome: A Pilot Study
نویسندگان
چکیده
منابع مشابه
Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in mice.
Human apolipoprotein E (APOE) exists in three isoforms ɛ2, ɛ3, and ɛ4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD). As cerebrovascular defects are associated with AD, we tested whether APOE genotype has an impact on the integrity and function of the blood-brain barrier (BBB) in human APOE-targeted replacement mice. Using the quantitative in situ brain perfusion te...
متن کاملProteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain
Down syndrome (DS) is one of the most common genetic causes of intellectual disability and is characterized by a number of behavioral as well as cognitive symptoms. Many of the neuropathological features of early-onset Alzheimer's disease (AD) including senile plaques and neurofibrillary tangles (NFTs) are also present in people with DS as a result of triplication of the amyloid precursor gene ...
متن کاملApolipoprotein E, B vitamins, and cognitive function in older adults.
Recognition of dated and contemporary famous faces, short-term memory, and visuospatial abilities were investigated in adults aged 75 years and older as a function of apolipoprotein E (APOE) genotype, epsilon4 or not epsilon4, and whether participants recorded normal or low levels of B vitamins. No associations between B vitamins and APOE were identified in respect to short-term memory or visuo...
متن کاملAltered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers
The APOE gene, encoding apolipoprotein E, is the primary genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E ɛ4 allele (APOE4) carriers have alterations in brain structure and function (as measured by brain imaging) even as young adults. Examination of this population is valuable in further identifying details of these functional changes and their association with vuln...
متن کاملEffect of Cognitive Pain Self-Management Program on Depression, Anxiety, and Stress in Women with Chronic Musculoskeletal Pain: A Pilot Study
Background: Chronic musculoskeletal pain is a worldwide health problem. Anxiety and depression are common among patients suffering from chronic pain. Self-management strategies are used to help patients manage the emotional distress associated with pain. Aim: To evaluate the effects of cognitive pain self-management program (CPSMP) on depression, anxiety, and stress in women with chronic pain....
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ژورنال
عنوان ژورنال: Archives of Clinical Neuropsychology
سال: 2016
ISSN: 0887-6177,1873-5843
DOI: 10.1093/arclin/acw022