Apoptosis of Hippocampal Neurons in Organotypic Slice Culture Models: Direct Effect of Bacteria Revisited
نویسندگان
چکیده
منابع مشابه
Organotypic hippocampal slice cultures.
The hippocampus, a component of the limbic system, plays important roles in long-term memory and spatial navigation. Hippocampal neurons can modify the strength of their connections after brief periods of strong activation. This phenomenon, known as long-term potentiation (LTP) can last for hours or days and has become the best candidate mechanism for learning and memory. In addition, the well ...
متن کاملEffect of TrkA and p75NTR on the Survival of Neurons in the Cultured Organotypic Hippocampal Slice
Background: Nerve growth factor (NGF) promotes the survival and differentiation of vertebrate neurons, and their actions are mediated by two classes of cell surface receptors: tyrosine kinase A receptor (TrkA) and p75 neurotrophic receptor (p75). We evaluated the role of NGF receptors in neuronal survival and the physical interactions between them. Methods: Organotypic hippocampal slices were o...
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Oxygen-glucose deprivation promotes gliogenesis and microglia activation in organotypic hippocampal slice culture: involvement of metalloproteinases.
Organotypic hippocampal cultures are used as an alternative model for studying molecular mechanism(s) of neurogenesis after combined oxygen-glucose deprivation (OGD) mimicking ischemic conditions. The aim of the present work was to investigate the effect of OGD on stem/progenitor cells proliferation and/or differentiation in the hippocampus. Our attention was primarily focused on the relationsh...
متن کاملThe rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model
The mouse subventricular zone (SVZ) generates large numbers of neuroblasts, which migrate in a distinct pathway, the rostral migratory stream (RMS), and replace specific interneurons in the olfactory bulb (OB). Here, we introduce an organotypic slice culture model that directly connects the RMS to the hippocampus as a new destination. RMS neuroblasts widely populate the hippocampus and undergo ...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2004
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/63.6.610