Apoptotic U1-70 kd is antigenically distinct from the intact form of the U1-70-kd molecule

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A major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein autoantigen.

Apoptotically modified forms of autoantigens have been hypothesized to participate in lupus immunopathogenesis. This study identifies a major B cell epitope present on the apoptotic but not the intact form of the U1-70-kDa ribonucleoprotein lupus autoantigen (70k). Human autoimmune sera with strong recognition of apoptotic 70k and minimal recognition of intact 70k were identified and tested for...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatism

سال: 2002

ISSN: 0004-3591,1529-0131

DOI: 10.1002/art.10211