Application of Bio-Inspired Gold Nanoparticles as Advanced Nanomaterial in Halt Nociceptive Pathway and Hepatotoxicity via Triggering Antioxidation System

This study aimed to investigate the pharmacological efficacy of gold nanoparticles (GNs) synthesized using a green route, employing rhizome extract Euphorbia wallichii (REEW) as bioreductant and surface stabilizing agent. The GNs were characterized by series complementary analytical techniques including SEM-EDX, XRD, DLS, IR spectroscopy. reducing ability REEW synthesis confirmed UV–visible absorption spectroscopy, presence spherical with an fcc geometry was further through SEM XRD analyses. role REEW’s agent towards verified FTIR electronic spectral measurement. GC-MS analysis showed 41 different phytochemicals in (chloromethyl 2-chloroundecanoate; cortisone; benzo[h]quinolone; piperidine, 2,4-dimethyl- 3,6,7-trimethoxyphenanthroindolizidine; 4-methyl-; 2-[2-quinolylmethyleneamino]ethanol, etc.), RT values ranging from 3.10 27.22 min. REEW-functionalized exhibited promising antioxidant against H2O2 *OH used probe molecules. DPPH scavenging test significant EC50 19.47 µg/mL, 13.53 10.57 µg/mL at 30, 60, 90 min incubation, respectively. Thermal nociceptive mice significantly acquired analgesia dose-dependent manner. Moreover, pre-treatment REEW-GNs restored serum ALT, AST, T.P, Bilirubin levels PCM-intoxicated mice. antidiabetic activity alloxan-induced diabetic rabbits fell orders metformin > 300 mg/kg b.w 200 100 saline 0.1 h drug administration. To sum up, functionalized have tremendous potential for curing degenerative/metabolic diseases caused result oxidative stresses.