Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing
نویسندگان
چکیده
منابع مشابه
Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
Concerns over cardiac side effects are the largest single cause of compound attrition during pharmaceutical drug development. For a number of years, biophysically detailed mathematical models of cardiac electrical activity have been used to explore how a compound, interfering with specific ion-channel function, may explain effects at the cell-, tissue- and organ-scales. With the advent of high-...
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Acknowledgements I would like to express my gratitude to Professor Alfio Quarteroni, who gave me the possibility to work within the Chair of Modeling and Scientific Computing (CMCS) to my Master Project, and to Luca Dedè, who was very supportive during these months and always available to provide valuable advice and ideas. My thanks go to everyone in the CMCS group, in particular to Andrea and ...
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Recently, significant achievements have beenmade in cardiac electrophysiology research, including Ca regulatory pathways, membrane ion channel-related intracellular signaling, and electrical remodeling in cardiomyopathies. The rapid progress in the basic research has led to applications of numerous new methods and strategies to clinical diagnoses and treatments. The efficacy of antiarrhythmic p...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2012
ISSN: 0007-1188,1476-5381
DOI: 10.1111/j.1476-5381.2012.02020.x