Application of gold nanoparticles–epoxy surface nanocomposites for controlling hotspot density on a large surface area for SERS applications

The applicability of a novel gold–epoxysurface nanocomposite for surface-enhanced Raman scattering (SERS) is investigated. consists ellipsoidal nanoparticles in hexagonal arrangement, where the average particle diameter (D0) and interparticle gap (D) can be controlled 0.15–1.00 (D/D0) range on large surface area (several cm 2). Numerical simulations were used to estimate SERS enhancement factors substrates with five different arrangements. fabricated substrates’ was functionalized 20 base-pair long double-stranded DNA molecules intensities characteristic peaks related quantify substrate performance. It proved that by optimizing fabrication parameters maximizing coupling, could increased more than 2.5 orders magnitude.