Applications of Hydrophobically-Modified Hydroxypropyl Methylcellulose to Topical Preparation. Part III. Effect of Hydrophobically-Modified Hydroxypropyl Methylcellulose on the Crystallization from Supersaturated Solutions of Indomethacin.
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Hydrophobically Modified Hydroxypropyl Methylcellulose in Rats
A six-month repeated-dose dermal toxicity study fo11owed by a 30-day recovery test of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC), a new ceLlulose derivative used as a thickener for topical pharmaceuticals, was conducted using rats, Aqueous paste of HM-HPMC was applied to the skin ofrats once daily at dose levels up to 60 mg/kglday, which was the highest dose that could be ...
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Hydroxy propyl methyl cellulose can be used in the development of different drug delivery technology. Nowadays it is a widely used polymer and different viscosity grade of this polymer is available. The hydrophilic and hydrophobic form (both variants) of this polymer is also available. This study includes a review of this polymer on use in different drug delivery system mosty focusing on more r...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1994
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.42.2320