Aptamer Displacement Identifies Alternative Small-Molecule Target Sites that Escape Viral Resistance
نویسندگان
چکیده
منابع مشابه
Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance.
Aptamers targeting reverse transcriptase (RT) from HIV-1 inhibit viral replication in vitro, presumably by competing with binding of the primer/template complex. This site is not targeted by the currently available small-molecule anti-HIV-1 RT inhibitors. We have identified SY-3E4, a small-molecule inhibitor of HIV-1 RT, by applying a screening assay that utilizes a reporter-ribozyme regulated ...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2007
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2007.06.003