Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway
نویسندگان
چکیده
منابع مشابه
Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity
Triptolide, the major active component of Tripterygium wilfordii Hook f. (TWHF), has a wide range of pharmacological activities. However, the toxicities of triptolide, particularly the hepatotoxicity, limit its clinical application. The hepatotoxicity of triptolide has not been well characterized yet. The aim of this study was to investigate the role of NF-E2-related factor 2 (Nrf2) in triptoli...
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Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is the master bile acid nuclear receptor and plays an important role in maintaining hepatic metabolism...
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2020
ISSN: 2314-6141,2314-6133
DOI: 10.1155/2020/2508952