Arsenic trioxide — An old drug rediscovered

Buttonhole: an old technique rediscovered.

Protective Effects of Eugenol against Hepatotoxicity Induced by Arsenic Trioxide: An Antileukemic Drug

Background: Arsenic trioxide (As2O3) has shown effectiveness in the treatment of leukemia, but it is also associated with hepatotoxicity. Given antileukemic drug-induced oxidative stress and toxicity, this study focused on the mitigatory role of eugenol, a monoterpene compound from clove oil, in the hepatic tissue of Wistar rats.Methods: Twenty-four male Wistar rats (180–250 g) were randomly di...

Clonidine: An Old Friend Newly Rediscovered

Implication for health policy/practice/research/medical education: Clonidine, a relatively old anti-hypertensive agent, has been used during the last years, as an analgesic agent. Nowadays, this drug has been used not only orally, but also, intravenously and interathechally; which possibly suggest newer mechanisms. There are emerging evidence for this fact. Copyright © 2011, ISRAPM, Published b...

Arsenic trioxide

At an acute ingestion of arsenic trioxide, nausea, vomiting, diarrhea, and abdominal pain are early symptoms occurring within 30 min to several hours. Primary target organ is the gastrointestinal tract (GIТ), where hemorrhagic gastroenteritis can occur in serious cases. Among cardiovascular symptoms are tachycardia, ventricular fibrillation, and heart failure described. Neurological symptoms ca...

Myocardial toxicity of acute promyelocytic leukaemia drug-arsenic trioxide.

BACKGROUND Arsenic trioxide (As2O3) is an environmental toxicant as well as an effective anti cancer agent against many types of cancers. It is a promising drug for patients with relapsed acute promyelocytic leukaemia (APL), but its clinical efficacy is burdened by the serious cardiac toxicities. AIM The present study was designed to investigate the toxic mechanism of arsenic in cardiac tissu...