Arsenic trioxide and neuroblastoma cytotoxicity
نویسندگان
چکیده
منابع مشابه
Arsenic trioxide and neuroblastoma cytotoxicity.
The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the child...
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Arsenic trioxide is a well-known environmental toxicant and carcinogen. However, arsenic trioxide has also been used clinically to treat some forms of human cancer (e.g. leukemia). Although its therapeutic effects have been studied extensively, the cellular and molecular mechanisms of its action on cancer cells are not fully elucidated. Hence, the aim of the present research was to evaluate cyt...
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BACKGROUND Arsenic is a ubiquitous environmental toxicant, and abnormalities of the skin are the most common outcomes of long-term, low-dose, chronic arsenic exposure. If the balance between keratinocyte proliferation, differentiation, and death is perturbed, pathologic changes of the epidermis may result, including psoriasis, atopic dermatitis, and certain forms of ichthyosis. Therefore, resea...
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At an acute ingestion of arsenic trioxide, nausea, vomiting, diarrhea, and abdominal pain are early symptoms occurring within 30 min to several hours. Primary target organ is the gastrointestinal tract (GIТ), where hemorrhagic gastroenteritis can occur in serious cases. Among cardiovascular symptoms are tachycardia, ventricular fibrillation, and heart failure described. Neurological symptoms ca...
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Despite intensive treatment, the outcome of high-risk neuroblastoma patients is poor with acquired multidrug resistance as an important cause. Previously, our group has shown that arsenic trioxide (As(2)O(3)) kills multidrug-resistant neuroblastoma cells in vitro and in vivo at clinically tolerable doses. Regions of tissue hypoxia often arise in aggressive solid tumors, and hypoxic tumors exhib...
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ژورنال
عنوان ژورنال: Journal of Bioenergetics and Biomembranes
سال: 2007
ISSN: 0145-479X,1573-6881
DOI: 10.1007/s10863-006-9058-6