Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure

Abstract Frailty is a common comorbidity associated with adverse events in patients heart failure, and early recognition key to improving its management. We hypothesized that the AST ALT ratio (AAR) could be marker of frailty failure. Data from FRAGILE-HF study were analyzed. A total 1327 aged ? 65 years hospitalized failure categorized into three groups based on their AAR at discharge: low (AAR < 1.16, n = 434); middle (1.16 ? 1.70, 487); high 406). The primary endpoint was one-year mortality. association between physical function also assessed. High lower short performance battery shorter 6-min walk distance, these associations independent age sex. Logistic regression analysis revealed an after adjustment for age, sex body mass index. During follow-up, all-cause death occurred 161 patients. After adjusting confounding factors, (low vs. AAR, hazard ratio: 1.57, 95% confidence interval, 1.02–2.42; P 0.040). In conclusion, prognostic mortality older