Assessing generalizability of trial results in general practice
نویسندگان
چکیده
منابع مشابه
Assessing generalizability of trial results in general practice.
The gold standard for assessing treatment effects is the randomized clinical trial. Providers are fortunate to have a robust set of trials with .80 000 participants showing important benefits and reassuring safety of the non-vitamin K oral anticoagulants (NOACs) relative to warfarin for stroke prevention in atrial fibrillation (AF). 4 Based on the consistent findings of these trials, providers ...
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BACKGROUND While results of clinical trials are used to impact practice among patients with ischemic stroke, very little information is available regarding proportion and characteristics of patients recruited in clinical trials in general practice. METHODS We performed this analysis to provide an audit of recruitment in clinical trials among patients with acute ischemic stroke using data from...
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A controlled double-blind trial of amitriptyline at two dosage levels (75 and 150 mg/day), amylobarbitone (150 mg/day), and an inert substance for a period of four weeks was conducted on four matched groups of women attending their general practitioners and suffering from a depressive illness. Improvement at 7 and 28 days was noted on several measures of depression and anxiety in all treatment ...
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BACKGROUND Non-participation of General Practitioners (GPs) hampers primary care research. Using existing network structures can improve participation, but may introduce sampling effects. OBJECTIVES To examine the role of network-based recruitment and other determinants of participation, and to estimate effects of sampling and non-participation on generalizability. METHODS For a study of qu...
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The issue of generalizability of clinical trial results has challenged researchers and practitioners of adult cancer patients for years. It is one reason why the adult cancer cooperative group enterprise in the United States is undergoing yet another transformation (1). Figure 1 may capture the essence of the situation. Its foreground shows the most recent data available to this commentator on ...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2015
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/ehv532