Assessing the Discordance of Multiple Sequence Alignments

Assessing Multiple Sequence Alignments Using Visual Tools

Multiple Sequence Alignments in Linguistics

In this study we apply and evaluate an iterative pairwise alignment program for producing multiple sequence alignments, ALPHAMALIG (Alonso et al., 2004), using as material the phonetic transcriptions of words used in Bulgarian dialectological research. To evaluate the quality of the multiple alignment, we propose two new methods based on comparing each column in the obtained alignments with the...

Evolving Better Multiple Sequence Alignments

Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal multiple sequence alignment is prohibitively expensive. Heuristic alignment algorithms represent a practical trade-off between speed and accuracy, but they can be improved. We present EVALYN (EVolved ALYNments), a novel...

Viewing multiple sequence alignments with the JavaScript Sequence

The JavaScript Sequence Alignment Viewer (JSAV) is designed as a simple-to-use JavaScript component for displaying sequence alignments on web pages. The display of sequences is highly configurable with options to allow alternative coloring schemes, sorting of sequences and ’dotifying’ repeated amino acids. An option is also available to submit selected sequences to another web site, or to other...

Evaluation Measures of Multiple Sequence Alignments

Multiple sequence alignments (MSAs) are frequently used in the study of families of protein sequences or DNA/RNA sequences. They are a fundamental tool for the understanding of the structure, functionality and, ultimately, the evolution of proteins. A new algorithm, the Circular Sum (CS) method, is presented for formally evaluating the quality of an MSA. It is based on the use of a solution to ...