Assessing the Impact of Differential Genotyping Errors on Rare Variant Tests of Association
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چکیده
منابع مشابه
Assessing the Impact of Differential Genotyping Errors on Rare Variant Tests of Association
Genotyping errors are well-known to impact the power and type I error rate in single marker tests of association. Genotyping errors that happen according to the same process in cases and controls are known as non-differential genotyping errors, whereas genotyping errors that occur with different processes in the cases and controls are known as differential genotype errors. For single marker tes...
متن کاملAssessing the impact of non-differential genotyping errors on rare variant tests of association.
BACKGROUND/AIMS We aim to quantify the effect of non-differential genotyping errors on the power of rare variant tests and identify those situations when genotyping errors are most harmful. METHODS We simulated genotype and phenotype data for a range of sample sizes, minor allele frequencies, disease relative risks and numbers of rare variants. Genotype errors were then simulated using five d...
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15 صفحه اولEvaluating the impact of genotype errors on rare variant tests of association
The new class of rare variant tests has usually been evaluated assuming perfect genotype information. In reality, rare variant genotypes may be incorrect, and so rare variant tests should be robust to imperfect data. Errors and uncertainty in SNP genotyping are already known to dramatically impact statistical power for single marker tests on common variants and, in some cases, inflate the type ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0056626