Assessment of Bronchodilator Responsiveness after Methacholine-Induced Bronchoconstriction
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چکیده
منابع مشابه
Assessment of Bronchodilator Responsiveness after Methacholine-Induced Bronchoconstriction
© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Spirometry is the only objective clinical tool available to physicians in the outpatient setting. Patient history is often unreliable and physical examinations are normal when the child doesn’t show symptoms. For that reason, spirometry is...
متن کاملAssessment of Bronchodilator Responsiveness Following Methacholine-Induced Bronchoconstriction in Children With Asthma
PURPOSE The aim of this study was to investigate bronchodilator responsiveness (BDR) following methacholine-induced bronchoconstriction and to determine differences in BDR according to clinical parameters in children with asthma. METHODS The methacholine challenge test was performed in 145 children with mild to moderate asthma, and the provocative concentration causing a 20% decline in FEV1 (...
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Asthma is a complex disease of airway inflammation, which results in airway remodeling and hyper-responsiveness.1 Because asthma-related symptoms are not specific to asthma, diagnosis requires objective data from pulmonary function tests (PFT). Bronchodilator responsiveness and airway responsiveness to provocational stimuli (eg, methacholine, dry-gas hyperpnea) help establish the diagnosis of a...
متن کاملMethacholine causes reflex bronchoconstriction.
To determine whether methacholine causes vagally mediated reflex constriction of airway smooth muscle, we administered methacholine to sheep either via the bronchial artery or as an aerosol via tracheostomy into the lower airways. We then measured the contraction of an isolated, in situ segment of trachealis smooth muscle and determined the effect of vagotomy on the trachealis response. Adminis...
متن کاملDynamic lung morphology of methacholine-induced heterogeneous bronchoconstriction.
Hyperpolarized (HP) 3helium (3He) dynamic MRI was used to investigate airway response in rats following intravenous (i.v.) bolus administration of a contractile agent, methacholine (MCh). The method provides direct visualization of the ventilated regions within the lung. Heterogeneous bronchoconstriction following the i.v. MCh injection was evident using this technique. These 3He dynamic lung i...
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ژورنال
عنوان ژورنال: Allergy, Asthma and Immunology Research
سال: 2011
ISSN: 2092-7355
DOI: 10.4168/aair.2011.3.4.215