Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles
نویسندگان
چکیده
منابع مشابه
Limitation of Simultaneous Analysis of T-Cell Receptor and κ-Deleting Recombination Excision Circles Based on Multiplex Real-Time Polymerase Chain Reaction in Common Variable Immunodeficiency Patients
Aim of Study: We used a triplex real-time polymerase chain reaction (PCR) to classify our common variable immunodeficiency (CVID) patients into distinct groups according to the amount of their T-cell receptor excision circles (TRECs) and κ-deleting recombination excision circles (KRECs). Materials and Methods: TREC and KREC analysis was performed using a multiplex real-time PCR assay. The Tand ...
متن کاملReevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants.
The human thymus exports newly generated T cells to the periphery. As no markers have been identified for these recent thymic emigrants (RTE), it is presently impossible to measure human thymic output. T cell receptor excision circles (TREC) have been recently used to assess thymic output during both health and disease. Using a mathematical model, we quantify age-dependent changes both in the n...
متن کاملThymic Emigrants Circles as a Measure of Human Recent Reevaluation of T Cell Receptor Excision
متن کامل
T Cell Abnormalities in Common Variable Immunodeficiency
1. Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran 3. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran 4. Department of Immunology...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2002
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2002.01893.x