Association of Noise Annoyance with Measured Renal Hemodynamic Changes

<b><i>Background:</i></b> Chronic mental stress is recognized as a modifiable risk factor for cardiovascular disease. The aim of this study was to demonstrate that noise annoyance-induced associated with changes in renal hemodynamics. <b><i>Methods:</i></b> Renal hemodynamic parameters were measured using steady-state input clearance infusion para-aminohippuric acid and inulin individuals normal, high elevated blood pressure. All ranked subjective annoyance due everyday life on 7-grade Likert scale. median all rankings used cutoff point divide the group into noise-annoyed non-noise-annoyed individuals. Different calculated based Gomez equation. <b><i>Results:</i></b> Noise-annoyed (<i>n</i> = 58) showed lower plasma flow (599 ± 106 vs. 663 124 mL/min, <i>p</i> 0.009), (1,068 203 1,172 225 0.047), higher filtration fraction (22.7 3.3 21.3 3.0, 0.012), vascular resistance (88.9 25.6 75.8 22.9 mm Hg/[mL/min], 0.002), afferent arteriole (2,439.5 1,253.4 1,849.9 1,242.0 dyn s<sup>−1</sup> cm<sup>−5</sup>, 0.001) compared 55). There no difference glomerular rate (133 11.8 138 15 0.181), efferent (2,419.4 472.2 2,245.8 370.3 0.060), intraglomerular pressure (64.0 3.1 64.6 3.5 Hg, 0.298) between groups. After adjusting age, flow, remained significantly different groups, trend increased arteriolar fraction. <b><i>Conclusion:</i></b> In study, reduced perfusion attributed predominantly at site. Long-term consequences pattern need be investigated.