Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

P15: Astrocyte Dysfunction in Epilepsy

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Mitochondrial Dysfunction & Neurological Disorders

Most of the living organisms derive their energy requirements from ingested food material through controlled metabolic reactions. Prokaryotes like bacteria obtain the ATP, the energy subunit from series of enzymatic reactions which occur in the cytosol [1]. In contrast to prokaryotes, eukaryotes have evolved a highly specialized double membrane organelles i.e., mitochondria encompassing electro...

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP pr...

Guns and Suicide: Correlation or Causation?

Zika and microcephaly: causation, correlation, or coincidence?