Asymmetric Catalysis Special Feature Part I: Catalytic enantioselective intermolecular cycloadditions of 2-diazo-3,6-diketoester-derived carbonyl ylides with alkene dipolarophiles
نویسندگان
چکیده
منابع مشابه
Photogeneration and Thermogeneration of Carbonyl Ylides: 1,3-dipolar Cycloadditions of 2,3-diaryloxiranes to Dipolarophiles*
A series of symmetrically substituted 2,3-diaryloxiranes 1 4 (Fig. 1) has been studied as photoprecursors for carbonyl ylides [l 31. The stereochemistry of the adducts obtained on the interception of these 4rzn transient system with a variety of dipolarophiles provides information on the mode(s) of electrocyclic opening of the oxiranes to carbonyl ylides as well as on the mechanism of the 4n + ...
متن کاملEnantioselective dearomative [3 + 2] cycloadditions of indoles with azomethine ylides derived from alanine imino esters†
Catalytic, enantioselective [3 + 2] cycloadditions of azomethine ylides derived from alanine imino esters with 3-nitroindoles are reported. The dearomative cycloaddition reactions occur in the presence of a catalyst generated in situ from Cu(OTf)2 and (R)-Difluorphos to form exo’-pyrroloindoline cycloadducts and establish four contiguous stereogenic centers, two of which are fully substituted. ...
متن کاملCatalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis
Cycloaddition reactions are among the most powerful methods for the synthesis of complex compounds. In particular, the development and application of the 1,3-dipolar cycloaddition, an important member of this reaction class, has grown immensely due to its powerful ability to efficiently build various five-membered heterocycles. Azomethine ylides are commonly used as dipoles for the synthesis of...
متن کاملDual catalysis in enantioselective oxidopyrylium-based [5 + 2] cycloadditions.
A new method for effecting catalytic enantioselective intramolecular [5 + 2] cycloadditions based on oxidopyrylium intermediates is reported. The dual catalyst system consists of a chiral primary aminothiourea and a second achiral thiourea. Experimental evidence points to a new type of cooperative catalysis with each species being necessary to generate a reactive pyrylium ion pair that undergoe...
متن کاملArchitectural and functional engineering of chiral molecular catalysts Asymmetric Catalysis Special Feature Part I: Toward efficient asymmetric hydrogenation:
www.pnas.org/cgi/content/full/101/15/5356#otherarticles This article has been cited by other articles: E-mail Alerts . click here at the top right corner of the article or Receive free email alerts when new articles cite this article sign up in the box Subspecialty Collections www.pnas.org/cgi/collection/asymm_catalysis Asymmetric Catalysis Special Feature collection(s): This article, along wit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0307274101