Asymmetric protein design from conserved supersecondary structures
نویسندگان
چکیده
منابع مشابه
Mining Conserved Topological Structures from Large Protein-Protein Interaction Networks
Analysis of Protein-Protein Interaction (PPI) networks is of great significance in evolutionary biology. Because of high computation cost, recently multi-PPI network alignment becomes hot topic. In this paper, we proposed conserved topological structures mining based multiPPI network alignment technology. The most challenging problems in conserved topological structure mining are the large size...
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The sequence-based prediction of the secondary and supersecondary structures enjoys strong interest and finds applications in numerous areas related to the characterization and prediction of protein structure and function. Substantial efforts in these areas over the last three decades resulted in the development of accurate predictors, which take advantage of modern machine learning models and ...
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We present a fragment-search based method for predicting loop conformations in protein models. A hierarchical and multidimensional database has been set up that currently classifies 105,950 loop fragments and loop flanking secondary structures. Besides the length of the loops and types of bracing secondary structures the database is organized along four internal coordinates, a distance and thre...
متن کاملPrediction of protein supersecondary structures based on the artificial neural network method.
The sequence patterns of 11 types of frequently occurring connecting peptides, which lead to a classification of supersecondary motifs, were studied. A database of protein supersecondary motifs was set up. An artificial neural network method, i.e. the back propagation neural network, was applied to the predictions of the supersecondary motifs from protein sequences. The prediction correctness r...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2018
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2018.10.010