At the leading edge of three-dimensional cell migration
نویسندگان
چکیده
منابع مشابه
At the leading edge of three-dimensional cell migration.
Cells migrating on flat two-dimensional (2D) surfaces use actin polymerization to extend the leading edge of the plasma membrane during lamellipodia-based migration. This mode of migration is not universal; it represents only one of several mechanisms of cell motility in three-dimensional (3D) environments. The distinct modes of 3D migration are strongly dependent on the physical properties of ...
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Zonula occludens (ZO)-1 is a multi-domain scaffold protein known to have critical roles in the establishment of cell-cell adhesions and the maintenance of stable tissue structures through the targeting, anchoring, and clustering of transmembrane adhesion molecules and cytoskeletal proteins. Here, we report that ZO-1 directly binds to MRCKβ, a Cdc42 effector kinase that modulates cell protrusion...
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Lin Huo, Wenyu Wen, Rui Wang, Chuen Kam, Jun Xia, Wei Feng* and Mingjie Zhang* Division of Life Science, Molecular Neuroscience Center, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, Department of Chemistry, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China and National Labo...
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Cell migration involves the cooperative reorganization of the actin-and microtubule cytoskeletons, as well as the turnover of cell-substrate adhesions, under the control of Rho family GTPases. RhoA is activated at the leading edge of motile cells by unknown mechanisms to control actin stress fiber assembly, contractility, and focal adhesion dynamics. The microtubule-associated guanine nucleotid...
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Transendothelial migration (TEM) is a tightly regulated process whereby leukocytes migrate from the vasculature into tissues. Rho guanosine triphosphatases (GTPases) are implicated in TEM, but the contributions of individual Rho family members are not known. In this study, we use an RNA interference screen to identify which Rho GTPases affect T cell TEM and demonstrate that RhoA is critical for...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.093732