AT1-receptor blockers: differences that matter
نویسندگان
چکیده
منابع مشابه
AT1-receptor blockers
finding of elevated leptin levels in cardiac failure patients stage NYHA II or III is supported by Filippatos et al. and others. From their data, however, it appears that leptin levels tend to decrease in cachectic patients with more advanced stages of the disease, which has only recently been confirmed by others. This does not necessarily contradict our observations. The patients reported in o...
متن کاملMechanistic differences of various AT1-receptor blockers in isolated vessels of different origin.
The functional inhibitory characteristics of the angiotensin II type 1 receptor blockers (ARB) candesartan; irbesartan; and losartan and its active metabolite EXP 3174 (EXP) were studied in rabbit aortic strips and rat portal vein preparations in vitro. Moreover, plasma-protein binding was determined, and the binding was high (>98. 5%) for all ARBs. These values were needed to relate the concen...
متن کاملAT1 receptor blockers for cognition decline after cardiac surgery?
AT1 Receptor Blockers for Cognition Decline After Cardiac Surgery? To the Editor: We read with interest the review article on stroke and encephalopathy after cardiac surgery1 and the related editorial.2 We agree that assessing these complications provides a unique clinical opportunity for evaluating preventive strategies because patients at higher risk can be identified before surgery. We would...
متن کاملComparison of the AT1-receptor blockers candesartan, irbesartan and losartan for inhibiting renal microvascular constriction.
Angiotensin II (Ang II) type 1 (AT1) receptor blockers differ in their affinity for the AT1-receptor, suggesting a dissimilar potency for inhibiting Ang II-induced vascular constriction. In the present study, we compared the effects of candesartan, irbesartan and losartan on the renal microvascular constriction to locally-formed Ang II, using isolated, perfused hydronephrotic rat kidneys. Addit...
متن کاملAT1-receptor response to non-saturating Ang-II concentrations is amplified by calcium channel blockers
BACKGROUND Blockers of angiotensin II type 1 receptor (AT1R) and the voltage gated calcium channel 1.2 (CaV1.2) are commonly used for treatment of hypertension. Yet there is little information about the effect of physiological concentrations of angiotensin II (AngII) on AT1R signaling and whether there is a reciprocal regulation of AT1R signaling by CaV1.2. METHODS To elucidate these question...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2002
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1001434