ATHEROMA PROGRESSION: PHYSICAL MODELING IN EXPERIMENTAL CARDIOLOGY

Prototype models of intra-arterial circulation is one the priority aims experimental cardiology, as well for study atherosclerosis. Purpose: To features hemodynamics in area of​​atheroma artery physical modeling. Materials and methods: We used an original "Device modeling circulation". The main parts model: glass rotameter tube form a truncated cylinder, inlet outlet ends which are fixed with elastic plastic tubes connected to electric water pump immersed container glycerol solution. Inside rotameter, using fitting from inlet, it possible install pressure sensor that transfers data oscilloscope; indicators - silk thread or dye ink. variable mode allowed us simulate regular heart rhythm, extrasystole (ES) atrial fibrillation (AF). Results: In first post-extrasystolic wave, turbulent fluid flow formed after plaque, standing waves reflected walls were observed; registered increase 1,6 times more compared rate wave. marginal plaque zones along against flow, especially areas bordering intact part arterial vessel, underwent mechanical impact. same patterns observed AF maximum duration pause between pulse ≥1,5 s. Conclusions: Heart arrhythmias play important role changes pathophysiological arteries danger not ES itself, but by contraction wave long ventricular contractions AF.