ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo
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چکیده
منابع مشابه
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.
Hsp90 is an abundant molecular chaperone essential to the establishment of many cellular regulation and signal transduction systems, but remains one of the least well described chaperones. The biochemical mechanism of protein folding by Hsp90 is poorly understood, and the direct involvement of ATP has been particularly contentious. Here we demonstrate in vitro an inherent ATPase activity in bot...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1998
ISSN: 1460-2075
DOI: 10.1093/emboj/17.16.4829