Atypical Adenomatous Hyperplasia and Well Differentiated Adenocarcinoma: Analysis by Morphometry, DNA index and Immunohistochemistry.
نویسندگان
چکیده
منابع مشابه
DNA Methylation Changes in Atypical Adenomatous Hyperplasia, Adenocarcinoma In Situ, and Lung Adenocarcinoma
BACKGROUND Aberrant DNA methylation is common in lung adenocarcinoma, but its timing in the phases of tumor development is largely unknown. Delineating when abnormal DNA methylation arises may provide insight into the natural history of lung adenocarcinoma and the role that DNA methylation alterations play in tumor formation. METHODOLOGY/PRINCIPAL FINDINGS We used MethyLight, a sensitive real...
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We assessed the occurrence of atypical adenomatous hyperplasia (AAH) in whole lung lobes with primary cancer lesions. Following surgical resection, tissue specimens were sliced to a thickness of 4 mm (3,641 specimens from 61 cases; mean = 59.7 specimens per case). A total of 119 AAH foci were found and an association was evident in 25 (57%) of 44 adenocarcinomas, 3 (30%) of 10 squamous cell car...
متن کاملGene amplification and protein expression of EGFR and HER2 by chromogenic in situ hybridisation and immunohistochemistry in atypical adenomatous hyperplasia and adenocarcinoma of the lung.
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It almost exclusively develops in the transition zone often within or adjacent to typical hyperplastic nodules and often multifocal. The prevalence of adenosis in transurethral prostatectomy specimens without cancer ranges from 1.6% to 7.3% (2). It has been detected in up to 33% of radical prostatectomy specimens (3). Due to uncommon sampling of the transition zone, it is rare in transrectal ne...
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ژورنال
عنوان ژورنال: Haigan
سال: 1999
ISSN: 1348-9992,0386-9628
DOI: 10.2482/haigan.39.125