Atypical Myosin Tunes Dendrite Arbor Subdivision
نویسندگان
چکیده
منابع مشابه
Intrinsic mechanisms to define neuron class-specific dendrite arbor morphology.
The class-specific transcription factors Knot and Cut act during dendrite arbor development to define the characteristic dendrite branching pattern of the Drosophila class IV dendritic arborisation sensory neurons. Knot mediates dendrite arbor outgrowth and branching via a microtubule-based program that includes upregulation of the microtubule severing protein Spastin. On the other hand, Cut pr...
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Astroglia play key roles in the development of neurons, ranging from regulating neuron survival to promoting synapse formation, yet basic questions remain about whether astrocytes might be involved in forming the dendritic arbor. Here, we used cultured hippocampal neurons as a simple in vitro model that allowed dendritic growth and geometry to be analyzed quantitatively under conditions where t...
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ژورنال
عنوان ژورنال: Neuron
سال: 2020
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2020.02.002