Authors' reply - Re: Wang et al. Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer

Authors' reply - Re: Wang et al. Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer.

We thank Wang et al for their interest in our article ‘Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over-expressed in cancer’ [1]. In their letter to the editor, ‘Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer’, Wang et al raise questions about the role of ASPM as a possible nove...

Controversial role of the possible oxyntic stem cell marker ASPM in gastric cancer.

We read with great interest the article by Vange et al [1] in the December 2015 issue of the Journal of Pathology, as well as the subsequent commentary by Zhu et al in the January 2016 issue [2]. Vange et al identified a novel possible oxyntic stem/progenitor cell marker ASPM [Asp (abnormal spindle) homologue, microcephaly-associated (Drosophila)] by genome-wide expression analysis of the micro...

Genome‐wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker over‐expressed in cancer

The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also proposed to be the potential cells-of-origin of gastric cancer, although little is known about their molecular characteristics and specific biological markers are lacking. In this...

The Authors’ Reply

The Authors’ Reply