Autocatalytic Processing of Clostridium difficile Toxin B
نویسندگان
چکیده
منابع مشابه
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate.
Clostridium difficile toxins A and B are major virulence factors responsible for induction of pseudomembranous colitis and antibiotic-associated diarrhea in men. The toxins possess a multidomain structure and only the N-terminal glucosyltransferase domain, which inactivates Rho GTPases by glucosylation, is translocated into the cytosol of target cells. Processing of the toxin occurs by autocata...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m806002200