Automated access to well-defined ionic oligosaccharides

Mitochondrial Haplogroups and Well Defined Populations

Automated synthesis of sialylated oligosaccharides

Sialic acid-containing glycans play a major role in cell-surface interactions with external partners such as cells and viruses. Straightforward access to sialosides is required in order to study their biological functions on a molecular level. Here, automated oligosaccharide synthesis was used to facilitate the preparation of this class of biomolecules. Our strategy relies on novel sialyl α-(2→...

Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation

Chitohexaose has attracted wide interest due to its special bioactivities and these potential activities are significantly related to N-acetylation. Herein, six chitohexaose fractions with different degrees of acetylation were prepared by selective N-acetylation and ion-exchange chromatography and further analyzed by ESI/MS. It is revealed that all the six N-acetylated chitohexaoses were of sin...

Automated Seismic-to-well Ties?

SUMMARY The quality of seismic-to-well tie is commonly quantified using the classical Pearson's correlation coefficient. However the seismic wavelet is time-variant, well logging and upscaling is only approximate, and the correlation coefficient does not follow this nonlinear behavior. We introduce the Dynamic Time Warping (DTW) to automate the tying process, accounting for frequency and time v...

Automated Glycan Assembly of Oligosaccharides Related to Arabinogalactan Proteins.

Arabinogalactan proteins are heavily glycosylated proteoglycans in plants. Their glycan portion consists of type-II arabinogalactan polysaccharides whose heterogeneity hampers the assignment of the arabinogalactan protein function. Synthetic chemistry is key to the procurement of molecular probes for plant biologists. Described is the automated glycan assembly of 14 oligosaccharides from four m...