Autophagy, apoptosis, vitamin D, and vitamin D receptor in hepatocellular carcinoma associated with hepatitis C virus
نویسندگان
چکیده
منابع مشابه
Significance of Vitamin D Receptor Gene Polymorphisms for Risk of Hepatocellular Carcinoma in Chronic Hepatitis C
BACKGROUND/AIMS Biological and epidemiological data suggest that vitamin D levels may influence cancer development. Several single nucleotide polymorphisms have been described in the vitamin D receptor (VDR) gene in association with cancer risk. We aimed to investigate the association of VDR gene polymorphisms with hepatocellular carcinoma (HCC) development in chronic hepatitis C patients. ME...
متن کاملThe Significance of Vitamin D Receptor Gene Polymorphisms for Susceptibility to Hepatocellular Carcinoma in Subjects Infected with Hepatitis C Virus
Vitamin D has pivotal immunomodulatory actions and emerging roles in hepatic pathophysiology, inflammatory and metabolic liver diseases. It is considered as a systemic hormone that is involved in metabolism, immune regulation, fibrogenesis and cancer development through its actions on Vitamin D receptor (VDR), an intracellular nuclear hormone receptor; subfamily 1, group1, member 1 (NR111) whic...
متن کاملVitamin D deficiency and vitamin D therapy in chronic hepatitis C.
BACKGROUND Vitamin D has immunomodulatory properties, exerts an anti-hepatitis C virus (HCV) effect in vitro and improves response to interferon-based therapy in patients with chronic hepatitis C (CHC). Low serum levels of 25(OH) vitamin D [25(OH)D] are frequently found in CHC patients and seem to be related to more advanced stages of liver fibrosis. The study aims to establish the incidence of...
متن کاملVitamin D, vitamin D receptor and tissue barriers
Tissue barriers are critical in the pathogenesis of human diseases, such as atopic dermatitis, inflammatory bowel diseases, and various cancers. Preserving or restoring barrier functions of the epithelia cells is a therapeutic strategy to prevent and treat the illness. Mounting evidence indicates that vitamin D and the vitamin D receptor (VDR) play key roles in the pathogenesis of human disease...
متن کاملEvaluation of relationship between BMI with vitamin D receptor gene expression and vitamin D levels of follicular fluid in overweight patients with polycystic ovary syndrome
Background Polycystic ovary syndrome (PCOS) is the most common endocrine disorder. The roles of vitamin D in the regulation of metabolic modulations specifically involving insulin action and reproduction processing are introduced. In addition, obesity appears to be closely associated with severity of PCOS. The aim of this study was to evaluate the effect of BMI on vitamin D levels in follicular...
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ژورنال
عنوان ژورنال: Medicine
سال: 2018
ISSN: 0025-7974
DOI: 10.1097/md.0000000000010172