Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth.
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Auxotrophs of Plasmodium falciparum dependent on p-aminobenzoic acid for growth.
The isolation of auxotrophic strains of a parasite offers new opportunities for studying parasitology. We have isolated cloned lines of Plasmodium falciparum that, unlike the parent line from which they were derived, rely on exogenous p-aminobenzoic acid (PABA) for growth. Isolation involved random mutagenesis of a cloned line of P. falciparum and subsequent selection of PABA-dependent parasite...
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Plasmodia species, unlike humans, can utilize p-aminobenzoic acid (PABA) for the de novo generation of folate. Plasmodial enzymes for the synthesis of PABA via the shikimate pathway are being investigated as novel targets for malaria chemotherapy. We show that, despite the presence of biosynthetic machinery to synthesize PABA, Plasmodium yoelii, a rodent malaria species, requires exogenous diet...
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According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملINTERRELATIONSHIP BETWEEN p-AMINOBENZOIC ACID AND PTEROYLGLUTAMIC ACID AS GROWTH FACTORS FOR LACTOBACILLI*
The elucidation of the structure of pteroylglutamic acid (PGA) (Lactobacillus casei factor, vitamin B,) has shown that p-aminobenzoic acid (PABA) is a component of the PGA molecule (1). Since earlier work has treated PABA and PGA as distinct growth factors for bacteria (2), it is now necessary to study the relationship in the utilization of these substances by bacteria. It has been shown that m...
متن کاملPlasmodium falciparum and P. malariae
Transmission of Plasmodium falciparum and P. malariae was studied in a village in Burkina Faso. Consecutive captures of mosquitos were organized twice a month over a year and the species of the mosquitos identified. Also, the prevalences and densities of Plasmodium spp. were determined every 2 months in a sample of children who lived in the village. Anopheles gambiae, A. funestus, and A. nili w...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1994
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.91.10.4244