Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing
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چکیده
منابع مشابه
Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing
Deposition of potentially neurotoxic Aβ fragments derived from amyloid precursor protein (APP) at synapses may be a key contributor to Alzheimer's disease. However, the location(s) of proteolytic processing and subsequent secretion of APP fragments from highly compartmentalized, euploid neurons that express APP and processing enzymes at normal levels is not well understood. To probe the behavio...
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The flotillins/reggie proteins are associated with noncaveolar membrane microdomains and have been implicated in the regulation of a clathrin- and caveolin-independent endocytosis pathway. Endocytosis is required for the amyloidogenic processing of the amyloid precursor protein (APP) and thus to initiate the release of the neurotoxic beta-amyloid peptide (Abeta), the major component of extracel...
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Alzheimer’s disease (AD) is today the most common form of dementia. It is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. APP belongs to a conser...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2015
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e14-06-1049