Axonal Regeneration, but Not Myelination, Is Partially Dependent on Local Cholesterol Reutilization in Regenerating Nerve
نویسندگان
چکیده
منابع مشابه
Axonal regeneration, but not myelination, is partially dependent on local cholesterol reutilization in regenerating nerve.
A recycling pathway in peripheral nerve permits cholesterol from degenerating myelin to be salvaged by macrophages and resupplied to myelinating Schwann cells by locally produced lipoproteins. A similar reutilization of cholesterol by regenerating axons has been proposed but not demonstrated. Neurites in culture, however, do take up cholesterol and cholesterol-containing lipoproteins, where the...
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متن کاملCholesterol synthesis and nerve regeneration.
In this report, we examine the requirement of cholesterol biosynthesis and its axonal transport for goldfish optic nerve regeneration. Cholesterol, labeled by intraocular injection of [3H]mevalonolactone, exhibited a delayed appearance in the optic tectum. Squalene and other minor components were labeled but not transported. Following optic nerve crush, the amount of labeled cholesterol transpo...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2000
ISSN: 0022-3069,1554-6578
DOI: 10.1093/jnen/59.11.1002