<b>A cell-based interferon-tau assay with an interferon-stimulated gene 15 pro</b><b>moter </b>
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چکیده
منابع مشابه
Interferon-stimulated gene 15 in hepatitis B-related liver diseases
This study investigates the association of Interferon-stimulated gene 15 (ISG15) polymorphisms, ISG15 serum levels and expression with HBV-related liver diseases. The ISG15 promoter and the two exons of the gene were screened for polymorphisms in 766 HBV-infected patients and in 223 controls. Soluble ISG15 levels were measured by ELISA. ISG15 mRNA expression was quantified by qRT-PCR in 36 tumo...
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Hepatitis B virus (HBV) is an important account of infectious hepatitis and interferon (IFN) remains one of the best treatment options. Activation of type I IFN signaling pathway leads to expressions of IFN-stimulated genes (ISGs) which play important roles in antiviral and immunomodulatory responses to HBV or hepatitis C virus (HCV) infection. Our previous studies indicated that ISG15 and its ...
متن کاملInterferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway
Interferon-stimulated gene 15 (ISG15) is an important cytokine that has been reported in carcinogenesis. However, we found that ISG15 and de-ISGylase USP18 were induced by several anti-cancer agents, which was confirmed by both RT-PCR and immunoblotting assays. Further studies demonstrated that ectopic ISG15 and USP18 inhibited proliferation of myeloma, leukemia and cervical cancer cells. More ...
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Type 1 diabetes, one of two major forms of diabetes, results from the complete destruction of pancreatic beta cells. Viral infection has been suggested to be a trigger of beta cell destruction, the pathogenesis of type 1 diabetes. The aim of this study was to clarify the role of the protein encoded by intherferon stimulated gene (ISG) 15, an antiviral effector, in the development of this clinic...
متن کاملDifferentiation-dependent activation of interferon-stimulated gene
We have recently shown that the adenovirus EIA gene products block interferon-a-induced signal transduction and transcription factor NF-cB-mediated gene induction. Here we report that the same responses are also blocked in undifferentiated F9 teratocarcinoma cells. The block was removed upon cellular differentiation and regained upon the introduction of viral EIA into the differentiated cells. ...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 2018
ISSN: 0388-6107,1880-313X
DOI: 10.2220/biomedres.39.13