BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

Differentiation by Controlling Dendritic Cell-Driven T Cell Elf3 Regulates Allergic Airway Inflammation

Elf3 belongs to the Ets family of transcription factors and has been implicated in inflammation. Elf3 is highly expressed in the lungs, and Elf3 2/2 mice are impaired in IL-6 production after intranasal LPS exposure. To identify the role of Elf3 in Th17-driven pulmonary inflammation, we have performed epicutaneous sensitization of Elf3 2/2 mice with OVA followed by airway OVA challenge and have...

Cell Effector and Memory Differentiation Signal Integration by Akt Regulates CD8 T

Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells

The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of the network of factors that regulates interleukin-2 expression. In primary and transformed CD4＋ T cells, Bach2 overexpression counteracted T cell ...

Transcriptional Enhancers in the Regulation of T Cell Differentiation

The changes in phenotype and function that characterize the differentiation of naïve T cells to effector and memory states are underscored by large-scale, coordinated, and stable changes in gene expression. In turn, these changes are choreographed by the interplay between transcription factors and epigenetic regulators that act to restructure the genome, ultimately ensuring lineage-appropriate ...

Bach2: plasma-cell differentiation takes a break.

Plasma cells are antibody-producing cells and represent the developmental end point of the B-cell lineage. Over the last few years, major progress has been made in understanding the transcriptional regulation of B-cell to plasmacell transition. Two transcription factors, Pax5 and Blimp1, are responsible for the development and maintenance of B-cell and plasma-cell identity, respectively. Both f...