Bacoside-A exerts protective effect against Parkinson’s disease-induced functional damage in mice via inhibition of apoptosis and oxidative response

Purpose: To determine the effect of bacoside-A on Parkinson's disease (PD) in a rat model, and elucidate its mechanism action.Methods: A model PD was established by administration 5 µL 6-hydroxydopamine ascorbic acid (0.1 %). Measurement serum levels inflammatory factors carried out using enzyme-linked immunosorbent assay (ELISA) kits. Western blotting used to Bax, cytochrome c Bcl-2 hippocampus.Results: Bacoside-A treatment significantly reduced PD-induced high turning values rats (p < 0.05). Treatment with reversed PD-mediated suppression activities CAT glutathione peroxidase (GPx). In bacoside-A-treated rats, dose-dependent acetylcholinesterase (AChE) inducible nitric oxide synthase (iNOS) were observed Bacoside-A-treated 0.018) interleukin (IL)-1β IL-6 levels. effectively tumor necrosis factor (TNF)-α, NF-κB p65, (COX)-2 p53 protein, also up-regulations C, caspase-3 caspase-9.Conclusion: exhibits protective against Parkinson disease-induced oxidative damage neuronal degeneration through downregulation iNOS, AChE, cytokines pro-apoptotic proteins. Therefore, has potentials for use management disease.
 Keywords: disease, Neuroprotective, Pro-apoptotic, Cytokines, Neurotoxicity